The Acute Phase Response to Parturition: A CrossSectional Study in Zimbabwe
), Exnevia Gomo(2), Wilson Mashange(3), Norman Nyazema(4), Pernille Kæstel(5), Frank Wieringa(6), Henrik Krarup(7),
(1)
(2)
(3)
(4)
(5)
(6)
(7)
Corresponding Author
Abstract
Parturition triggers an acute phase response, but its magnitude, duration and predictors are not well described. We determined serum α1-antichymotrypsin (ACT) and C-reactive protein (CRP) among 216 women attending postpartum services in south-eastern Zimbabwe. Serum CRP peaked during the first week and serum ACT around 9 days postpartum. Serum ACT, but not serum CRP, was lower among HIV infected women. Multiparity was a negative, and preterm delivery and caesarean section were positive predictors of both serum ACT and CRP. There is a need for a better understanding of the acute phase response to parturition (Afr J Reprod Health 2009; 13[2]:61-68).
RĖSUMĖ
Réponse de la phase aiguë a la parturition: une étude transversale au Zimbabwe. La parturition déclenché une réponse de la phase aiguë, mais son ampleur, sa durée et ses indices ne Sont pas bien décrits. Nous avons détermine la sérique alpha-antichymotrypsin (AAT) et la protéine C-réactive (PCR) chez 216 femmes qui fréquentaient les services du post-partum au sud-est du Zimbabwe. La sérique PCR a atteint le maximum au cours de la première semaine et la sérique AAT après un post-partum d’à peu près neuf jours. La sérique AAT (non pas la sérique PCR) était moins élevée chez les femmes séropositives. La multiparité était un indice négatif, tandis que l’accouchement avant terme et l’opération césarienne étaient des indices positifs de la sérique AAT et PCR. Il faut une meilleure compréhension de la réponse de la phase aiguë à la parturition (Afr J Reprod Health 2009; 13[2]:61-68).
KEYWORDS: Acute phase response, α1-antichymotrypsin, C-reactive protein, HIV, postpartum, Zimbabwe
References
Dinarello CA. Interleukin-1 and the pathogenesis of the acute-phase response. N Engl J Med 1984;311:1413-1418.
Filteau SM, Tomkins AM. Micronutrients and tropical infections. Trans R Soc Trop Med Hyg 1994;88:1-3, 26.
Friis H, Gomo E, Koestel P, Ndhlovu P, Nyazema N, Krarup H, Michaelsen KF. HIV and other predictors of serum beta-carotene and retinol in pregnancy: a cross-sectional study in Zimbabwe. Am J Clin Nutr 2001;73:1058-1065.
Friis H, Gomo E, Koestel P, Ndhlovu P, Nyazema N, Krarup H, Michaelsen KF. HIV and other predictors of serum folate, serum ferritin, and hemoglobin in pregnancy: a cross-sectional study in Zimbabwe. Am J Clin Nutr 2001;73:1066-1073.
Kongsbak K, Wahed MA, Friis H, Thilsted SH. Acute phase protein levels, T. trichiura, and maternal education are predictors of serum zinc in a cross-sectional study in Bangladeshi children. J Nutr 2006;136:22622268.
Thurnham DI, McCabe GP, Northrop-
Clewes CA, Nestel P. Effects of subclinical infection on plasma retinol concentrations and assessment of prevalence of vitamin A deficiency: meta-analysis Lancet 2003; 362:2052-2058.
Cicarelli LM, Perroni AG, Zugaib M, de Albuquerque PB, Campa A. Maternal and cord blood levels of serum amyloid A, Creactive protein, tumor necrosis factor-alpha, interleukin-1beta, and interleukin-8 during and after delivery. Mediators Inflamm 2005;2005:96-100.
Krarup HB, Drewes AM, Madsen PH. A quantitative HCV-PCR test for routine diagnostics. Scand J Clin Lab Invest 1998;58:415-422.
Grajeda R, Perez-Escamilla R. Stress during labor and delivery is associated with delayed onset of lactation among urban Guatemalan women. J Nutr 2002;132:3055-3060.
Keski-Nisula L, Kirkinen P, Ollikainen M, Saarikoski S. C-reactive protein in uncomplicated parturients delivered by cesarean section. Acta Obstet Gynecol Scand 1997;76:862-867.
Wasiluk A, Dabrowska M, Jaworski S, Prokopowicz J. The concentration of alpha 1antitrypsin in the maternal serum after delivery of normal and small for gestational age infants. Z Geburtshilfe Neonatol 2000;204:229-231.
Drabik MD, Schnure FC, Mok KT,
Moldawer LL, Dinarello CA, Blackburn GL, Bistrian BR. Effect of protein depletion and short-term parenteral refeeding on the host response to interleukin 1 administration. J Lab Clin Med 1987;109:509-516.
Jennings G, Elia M. Independent effects of protein and energy deficiency on acute-phase protein response in rats. Nutrition 1991;7:430-434.
Castell JV, Gomez-Lechon MJ, David M, Andus T, Geiger T, Trullenque R, Fabra R, Heinrich PC. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 1989;242:237-239.
Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr 2006;26:323-342.
Ross DA. Recommendations for vitamin A supplementation. J Nutr 2002;132:2902S2906S.
Ayah RA, Mwaniki DL, Magnussen P, Tedstone AE, Marshall T, Alusala D, Luoba A, Kaestel P, Michaelsen KF, Friis H. The effects of maternal and infant vitamin A supplementation on vitamin A status: a randomised trial in Kenya. Br J Nutr
Article Metrics
Abstract View
: 397 times
Download : 0 times
Refbacks
- There are currently no refbacks.
