1. Home
  2. Vol 29, No 5 (2025)
  3. Shen

Effects of kuntai capsule in combination with hormone replacement therapy on premature ovarian failure and bone metabolism

Aidong Shen(1), Yajun Ren(2), Jing Ling(3), Junxu Zhou(4), Yangyan Sun(5),


(1) Center for Bone Joint, Jiangyin Clinical College, Xuzhou Medical University, Jiangsu Province, China
(2) Center for Bone Joint, Jiangyin Clinical College, Xuzhou Medical University, Jiangsu Province, China
(3) Department of Gynecology, Jiangyin Clinical College, Xuzhou Medical University, Jiangsu Province, China
(4) Department of Gynecology, Jiangyin Clinical College, Xuzhou Medical University, Jiangsu Province, China
(5) Department of Gynecology, Jiangyin Clinical College, Xuzhou Medical University, Jiangsu Province, China
Corresponding Author

Abstract


This study evaluates the clinical effectiveness of combining kuntai capsule with hormone replacement therapy (HRT) in treating premature ovarian failure (POF) and its impact on ovarian reserve and bone metabolism. A total of 190 POF patients were randomly assigned to either a control group (n=95) receiving HRT alone (1 mg estradiol valerate tablets and 10 mg dydrogesterone tablets), or an observation group (n=95) receiving a combination of HRT and Kuntai Capsule. After three months of treatment, the observation group showed significantly better ovarian reserve, with a higher overall effective rate (87.37% vs. 71.58%). Hormonal analysis revealed lower follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, and higher estradiol (E2) levels in the observation group compared to the control. Furthermore, ovarian reserve markers such as anti-Müllerian hormone (AMH) and antral follicle count were also higher in the observation group. Bone metabolism improvements were noted, with higher osteocalcin (OST) and lower bone-specific alkaline phosphatase (BAP) levels. The observation group also had a significantly lower recurrence rate (7.3%) after 24 months, compared to the control group (16.8%). These results suggest that the combination of Kuntai Capsule and HRT offers a promising treatment for POF, improving ovarian function, hormone levels, and bone health while reducing recurrence risk.

References


Szeliga A, Calik-Ksepka A, Maciejewska-Jeske M,

Grymowicz M, Smolarczyk K, Kostrzak A,

Smolarczyk R, Rudnicka E and Meczekalski B.

Autoimmune Diseases in Patients with Premature

Ovarian Insufficiency-Our Current State of

Knowledge. Int J Mol Sci 2021, 22(5).

Wang J, Sun X, Yang Z, Li S, Wang Y, Ren R, Liu Z and Yu

D. Epigenetic regulation in premature ovarian failure:

A literature review. Front Physiol 2022, 13(998424.

Bai X and Wang S. Signaling pathway intervention in

premature ovarian failure. Front Med (Lausanne)

, 9(999440.

Chon SJ, Umair Z and Yoon MS. Premature Ovarian

Insufficiency: Past, Present, and Future. Front Cell

Dev Biol 2021, 9(672890.

Li Z, Qi H, Li Z, Bao Y, Yang K and Min Q. Research

progress on the premature ovarian failure caused by

cisplatin therapy. Front Oncol 2023, 13(1276310.

Wang Y, Jiang J, Zhang J, Fan P and Xu J. Research Progress

on the Etiology and Treatment of Premature Ovarian

Insufficiency. Biomed Hub 2023, 8(1):97-107.

Svejme O, Ahlborg HG, Nilsson JA and Karlsson MK. Early

menopause and risk of osteoporosis, fracture and

mortality: a 34-year prospective observational study

in 390 women. BJOG 2012, 119(7):810-816.

Samak MA, Abdelrahman AA, Samy W, Abdelrahman SA.

Combined Bazedoxifene and Genistein Ameliorate

Ovariectomy-Induced

Hippocampal

Alterations

via

Neuro

Activating CREB/BDNF/TrkB

Signaling

Pathway. Curr Mol Pharmacol.

;16(6):664-681.

Sullivan SD, Sarrel PM and Nelson LM. Hormone

replacement therapy in young women with primary

ovarian insufficiency and early menopause. Fertil

Steril 2016, 106(7):1588-1599.

Zhang S, Wang L, Zhang J, An W and Jia L. The efficacy

and safety of Kuntai capsule combined with

leuprorelin acetate in the treatment of endometriosis:

A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021, 100(11):e25080.

Zhang J, Fang L, Shi L, Lai Z, Lu Z, Xiong J, Wu M, Luo

A and Wang S. Protective effects and mechanisms

investigation of Kuntai capsule on the ovarian

function of a novel model with accelerated aging

ovaries. J Ethnopharmacol 2017, 195(173-181.

Gao H, Xia T, Ma R, Zhao ZORC, Wang B, Song X, Liu L,

Han K, Wang G, Fu Y and Hao G. Heyan Kuntai

capsule versus dehydroepiandrosterone in treating

Chinese patients with infertility caused by diminished

ovarian reserve: a multicenter, randomized controlled

trial. J Tradit Chin Med 2017, 37(4):530-537.

Liu FX and Sun Y. Identification of the active ingredients

and pharmacological effects of Kuntai capsules in the

treatment of primary ovarian insufficiency: A review.

Medicine (Baltimore) 2023, 102(21):e33884.

Ma Q, Tan Y and Mo G. Effectiveness of Cotreatment with

Kuntai Capsule and Climen for Premature Ovarian

Failure: A Meta-Analysis. Evid Based Complement

Alternat Med 2020, 2020(4367359.

Zhang X, Zhang L, Xiong L, Liu X, Zhang J, Yu F, Li Y,

Chang W and Chen W. Kuntai capsule for the

treatment of diminished ovarian reserve: A

systematic review and meta-analysis of randomized

controlled trials. J Ethnopharmacol 2024, 329(118167.

Tang X, Huang Q, Wang C, Zhang D, Dong S and Yu C.

Kuntai Capsule Combined With Letrozole on

Gonadal Hormone Levels and Ovarian Function in

Patients With PCOS: A Systematic Review and

Meta-Analysis. Front Endocrinol (Lausanne) 2021,

(789909.

Zhong HZ, Li MY, Yin XL, Bin CL, Zhou SY and Wei SB.

Chinese patent medicines combined with hormone

replacement therapy for premature ovarian failure: A

Bayesian network meta-analysis. Front Med

(Lausanne) 2022, 9(1043390.

Cai L, Zong DK, Tong GQ and Li L. Apoptotic mechanism

of premature ovarian failure and rescue effect of

Traditional Chinese Medicine: a review. J Tradit

Chin Med 2021, 41(3):492-498.

Pargianas M, Salta S, Apostolopoulou K, Lazaros L,

Kyrgiou M, Tinelli A, Malvasi A, Kalogiannidis I,

Georgiou I and Kosmas IP. Pathways Involved in

Premature Ovarian Failure: A Systematic Review of

Experimental Studies. Curr Pharm Des 2020,

(18):2087-2095.

Freitas ATA, Donovan Giraldo AE, Pravatta Rezende G,

Yela DA, Jales RM and Benetti-Pinto CL. Body

composition in women with premature ovarian

insufficiency using hormone therapy and the relation

to cardiovascular risk markers: A case-control study.

Clin Endocrinol (Oxf) 2021, 94(1):111-118.

Polakova M. Specifics of infertility treatment in women

with premature ovarian failure. Ceska Gynekol 2023,

(2):131-134.

Lin J, Li XL, Song H, Li Q, Wang MY, Qiu XM, Li DJ and

Wang L. A general description for Chinese medicine

in treating premature ovarian failure. Chin J Integr

Med 2017, 23(2):91-97.

Chen H, Zhang G, Peng Y, Wu Y, Han X, Xie L, Xu H,

Chen G, Liu B, Xu T, Pang M, Hu C, Fan H, Bi Y,

Hua Y, Zhou Y and Luo S. Danggui Shaoyao San

protects

cyclophosphamide-induced

premature

ovarian failure by inhibiting apoptosis and oxidative

stress through the regulation of the SIRT1/p53

signaling pathway. J Ethnopharmacol 2024,

(117718.

Sato T, Kusuhara A, Kasahara Y, Haino T, Kishi H and

Okamoto A. Follicular development during hormone

replacement therapy in patients with premature

ovarian insufficiency. Reprod Med Biol 2021,

(2):234-240.

Hamoda H and Sharma A. Premature ovarian insufficiency,

early menopause, and induced menopause. Best Pract

Res Clin Endocrinol Metab 2024, 38(1):101823.

Craciunas L, Zdoukopoulos N, Vinayagam S and

Mohiyiddeen L. Hormone therapy for uterine and

endometrial development in women with premature

ovarian insufficiency. Cochrane Database Syst Rev

, 10(10):CD008209.

Ding X, Lv S, Guo Z, Gong X, Wang C, Zhang X and Meng

K. Potential Therapeutic Options for Premature

Ovarian Insufficiency: Experimental and Clinical

Evidence. Reprod Sci 2023, 30(12):3428-3442.

Genazzani AR, Monteleone P, Giannini A and Simoncini T.

Hormone therapy in the postmenopausal years:

considering benefits and risks in clinical practice.

Hum Reprod Update 2021, 27(6):1115-1150.

Li WJ, Xu LZ, Liu HW, Zhang J, Tang LL, Zhou LL,

Zhuang J, Liu Y and Liu XF. [Effects of Kuntai

Capsule and hormone replacement therapy on

cognitive function and mental symptoms of early

postmenopausal women: a randomized controlled

trial]. Zhong Xi Yi Jie He Xue Bao 2010, 8(4):321

Zhou Q, Tao J, Song H, Chen A, Yang H, Zuo M and Li H.

Chinese herbal medicine Kuntai capsule for treatment

of menopausal syndrome: a systematic review of

randomized clinical trials. Complement Ther Med

, 29(63-71.

Liang R, Liu Z, Li P, Fan P, Xu L, Sun X, Peng J, Peng X

and Zhang M. Kuntai capsules improve glucolipid

metabolism in patients with polycystic ovary

syndrome: A randomized, double-blind, placebo

controlled trial. Medicine (Baltimore) 2019,

(39):e16788.

Qi X, Guo Y and Sun L. Effects of Kuntai capsule on breast

pain and vaginal bleeding in postmenopausal women.

Pak J Pharm Sci 2019, 32(5(Special)):2471-2476.


Full Text: PDF

Article Metrics

Abstract View : 1651 times
PDF Download : 508 times

Refbacks

  • There are currently no refbacks.