Efficacy of recombinant human collagen serum for improving skin dryness and roughness in striae gravidarum: a clinical study

Chenxing Li, Junguang Hou, Yan Yao, Li Zhou, Jing Chen

Abstract

Striae gravidarum is common after pregnancy and may be accompanied by skin dryness, roughness, and visible textural irregularity that affect quality of life. This prospective, self-controlled clinical study evaluated whether a topical recombinant human collagen serum could improve the biophysical characteristics of postpartum striae gravidarum. Twenty postpartum women with bilateral abdominal striae applied the serum twice daily to one randomly assigned abdominal side for 4 weeks, while the contralateral side served as the within-participant control. Skin elasticity, firmness, striae area, and surface roughness were assessed at baseline, week 2, and week 4 using standardized non-invasive instruments and digital image analysis. Longitudinal modeling showed greater improvement on the treated side than on the control side, particularly for elasticity, visible striae area, and surface roughness. Multivariate analysis indicated that reductions in striae area and roughness occurred in a coordinated pattern, suggesting overall structural improvement of the affected skin. The serum was well tolerated, with only mild transient erythema in two participants. These findings indicate that recombinant human collagen serum is a promising non-invasive option for improving postpartum striae gravidarum-related dryness, roughness, and skin texture.

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References

Kasielska-Trojan A, Sobczak M and Antoszewski B. Risk factors of striae gravidarum, International Journal of Cosmetic Science, 2015;37(2):236-40. https://doi.org/10.1111/ics.12188

Farahnik B, Park K, Kroumpouzos G and Murase J. Striae gravidarum: Risk factors, prevention, and management, International Journal of Womens Dermatology, 2016;3(2):77-85. https://doi.org/10.1016/j.ijwd.2016.11.001

Forbat E and Al-Niaimi F. Treatment of striae distensae: An evidence-based approach, Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology, 2019;21(1):49-57. https://doi.org/10.1080/14764172.2017.1418515

Xiong L, Yang L, He H, Chen J, Wang Y, Dong X, Li L and Han Y. Striae gravidarum in the Han Chinese pregnant population: identifying genetic markers and risk factors through a prospective cohort study, BMC Pregnancy and Childbirth, 2025;25(1):1075. https://doi.org/10.1186/s12884-025-08144-4

Yamaguchi K, Suganuma N and Ohashi K. Quality of life evaluation in Japanese pregnant women with striae gravidarum: a cross-sectional study, BMC Research Notes, 2012;5:450. https://doi.org/10.1186/1756-0500-5-450

Osman H, Rubeiz N, Tamim H and Nassar AH. Risk factors for the development of striae gravidarum, American Journal of Obstetrics and Gynecology, 2007;196(1):61-2. https://doi.org/10.1016/j.ajog.2006.08.044

Yu Y, Wu H, Yin H and Lu Q. Striae gravidarum and different modalities of therapy: a review and update, The Journal of Dermatological Treatment, 2022;33(3):1243-51. https://doi.org/10.1080/09546634.2020.1825614

Rawlings AV, Bielfeldt S and Lombard KJ. A review of the effects of moisturizers on the appearance of scars and striae, International Journal of Cosmetic Science, 2012;34(6):519-24. https://doi.org/10.1111/j.1468-2494.2012.00751.x

Atwal GSS, Manku LK, Griffiths CEM and Polson DW. Striae gravidarum in primiparae, British Journal of Dermatology, 2006;155(5):965-9. https://doi.org/10.1111/j.1365-2133.2006.07427.x

Salter SA and Kimball AB. Striae gravidarum, Clinics in Dermatology, 2006;24(2):97-100. https://doi.org/10.1016/j.clindermatol.2005.10.008

Tunzi M and Gray GR. Common skin conditions during pregnancy, American Family Physician, 2007;75(2):211-8.

Quan T and Fisher GJ. Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review, Gerontology, 2015;61(5):427-34. https://doi.org/10.1159/000371708

Ud-Din S, McGeorge D and Bayat A. Topical management of striae distensae (stretch marks): prevention and therapy of striae rubrae and albae, Journal of the European Academy of Dermatology and Venereology : JEADV, 2016;30(2):211-22. https://doi.org/10.1111/jdv.13223

Jie IWK, Lee KWA, Yoon SE, Song JK, Chan LKW, Lee CH, Jeong E, Kim JH and Yi KH. Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review, Life-Basel, 2025;15(4):582. https://doi.org/10.3390/life15040582

Tao L, Yi Y. Recombinant Type III Humanized Collagen Solution for Injection Improves Skin Photoaging in Chinese Population: A Case Series, J Cosmet Dermatol, 2025;24(7):e70276. https://doi.org/10.1111/jocd.70276.

Dobrev HP. A study of human skin mechanical properties by means of Cutometer, Folia Medica, 2002;44(3):5-10.

John AJUK, Galdo FD, Gush R and Worsley PR. An evaluation of mechanical and biophysical skin parameters at different body locations, Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2023;29(2):e13292. https://doi.org/10.1111/srt.13292

Roessle A and Kerscher M. Objectification of Skin Surface Evenness: In Vivo Evaluation of 300 Women in Relation to Age, Journal of Cosmetic Dermatology, 2025;24 Suppl 4(Suppl 4):e70383. https://doi.org/10.1111/jocd.70383

Schober P and Vetter TR. Linear Mixed-Effects Models in Medical Research, Anesthesia and Analgesia, 2021;132(6):1592-3. https://doi.org/10.1213/ANE.0000000000005541

Achana F, Gallacher D, Oppong R, Kim S, Petrou S, Mason J and Crowther M. Multivariate Generalized Linear Mixed-Effects Models for the Analysis of Clinical Trial-Based Cost-Effectiveness Data, Medical Decision Making : An International Journal of the Society for Medical Decision Making, 2021;41(6):667-84. https://doi.org/10.1177/0272989X211003880

Zhang Z and Castelló A. Principal components analysis in clinical studies, Annals of Translational Medicine, 2017;5(17):351. https://doi.org/10.21037/atm.2017.07.12

Ferguson AR, Irvine KRAMD, Gensel JC, Nielson JL, Lin A, Ly J, Segal MR, Ratan RR, Bresnahan JC and Beattie MS. Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats, PLoS One, 2013;8(3):e59712. https://doi.org/10.1371/journal.pone.0059712

Duan X, Ding C, Wu J, Bao W, Gao Y, Liu F and Cai W. Recombinant Type III Humanized Collagen Solution for Injection Promotes Skin Repair in Chinese Population: A Case Series, Journal of Cosmetic Dermatology, 2025;24(5):e70226. https://doi.org/10.1111/jocd.70226

Hermanns JF and Piérard GE. High-resolution epiluminescence colorimetry of striae distensae, Journal of the European Academy of Dermatology and Venereology, 2006;20(3):282-7. https://doi.org/10.1111/j.1468-3083.2006.01426.x

La Padula S, Hersant B, Pizza C, Chesné C, Jamin A, Ben Mosbah I, D'Andrea F, Persichetti P, Rega U, Pensato R and Meningaud JP. The Objective Stretch Marks Photonumeric Assessment Scale: A New and Complete Method to Assess Striae Distensae, Plastic and Reconstructive Surgery, 2023;151(2):307-13. https://doi.org/10.1097/PRS.0000000000009835

Neto PCA, Ferreira M, Bahia F and Costa P. Improvement of the methods for skin mechanical properties evaluation through correlation between different techniques and factor analysis, Skin Research and Technology: Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2013;19(4):405-16. https://doi.org/10.1111/srt.12060

Kim MA, Kim EJ and Lee HK. Use of SkinFibrometer(®) to measure skin elasticity and its correlation with Cutometer(®) and DUB(®) Skinscanner, Skin Research and Technology : Official Journal of International

Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2018;24(3):466-71. https://doi.org/10.1111/srt.12455

Schober P and Vetter TR. Repeated Measures Designs and Analysis of Longitudinal Data: If at First You Do Not Succeed-Try, Try Again, Anesthesia and Analgesia, 2018;127(2):569-75.https://doi.org/10.1213/ANE.0000000000003511

Zullig LL, Deschodt M, Liska J, Bosworth HB and De Geest S. Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science, Annu Rev Pharmacol Toxicol, 2019;59:423-445.https://doi.org/10.1146/annurev-pharmtox-010818-021348.

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