Prevalence, associated factors, and pharmacotherapy of hypertensive disorders among parturients in Bono Region of Ghana: An analytical cross-sectional study
), Edward T. Dassah(2), Jonathan Boakye-Yiadom(3), Kwadwo Addai-Darko(4), Bernard Okyere(5), Kwame O. Buabeng(6),
(1) Department of Pharmaceutical Sciences, Faculty of Applied Science, Sunyani Technical University, Sunyani, Bono Region, Ghana. Department of Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ashanti Region, Ghana.
(2) Department of Population, Family and Reproductive Health, School of Public Health, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ashanti Region, Ghana
(3) Department of Epidemiology and Biostatistics, School of Public Health, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ashanti Region, Ghana
(4) Department of Obstetrics and Gynecology, Sunyani Teaching Hospital, Sunyani, Bono Region, Ghana
(5) Department of Obstetrics and Gynecology, Sunyani Teaching Hospital, Sunyani, Bono Region, Ghana
(6) Department of Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ashanti Region, Ghana; School of Pharmacy, University of Health and Allied Sciences, Ho, Volta Region, Ghana
Corresponding Author
Abstract
References
WHO. Acceleration towards the sustainable development
goal targets for maternal health and child mortality.
Report by the Director-General, 2023. Available
from:
https://apps.who.int/gb/ebwha/pdf_files/EB154/B15
_12-en.pdf
Bajpai D, Popa C, Verma P, Dumanski S and Shah, S.
Evaluation and management of hypertensive
disorders of pregnancy. Kidney 360 2023; 4(10):
–1525.
Say L, Chou D, Gemmill A, Tuncalp O, Moller AB, Daniels
J, Gülmezoglu AM, Temmerman M and Alkema L.
Global causes of maternal death: A WHO systematic
analysis. Lancet Glob Heal 2014; 2(6): e323–e333.
Wang W, Xie X, Yuan T, Wang Y, Zhao F, Zhou Z and
Zhang H. Epidemiological trends of maternal
hypertensive disorders of pregnancy at the global,
regional, and national levels: A population‐based
study. BMC Pregnancy Childbirth 2021; 21(1): 364.
Noubiap JJ, Bigna JJ, Nyaga UF, Jingi AM, Kaze AD,
Nansseu JR and Fokom Domgue J. The burden of
hypertensive disorders of pregnancy in Africa: A
systematic review and meta-analysis. J Clin
Hypertens (Greenwich) 2019; 21(4): 479–488.
Naderi T, Foroodnia S, Omidi S, Samadani F and Nakhaee
N. Incidence and correlates of maternal near miss in
southeast Iran. Int J Reprod Med 2015; 2015:
Lotufo FA, Parpinelli MA, Haddad SM, Surita FG and
Cecatti, J. Applying the new concept of maternal
near-miss in an intensive care unit. Clin. (Sao Paulo)
; 67(3): 225–230.
WHO. Maternal mortality. 2024 Apr 26. Available from:
https://www.who.int/news-room/fact
sheets/detail/maternal-mortality.
Maternal mortality ratio (modeled estimate, per 100,000 live
births) -United States. WHO, UNICEF, UNFPA,
World Bank Group, and UNDESA/Population
Division. Trends in Maternal Mortality 2000 to 2020.
Geneva, 2023. Available from:
https://data.worldbank.org/indicator/SH.STA.MMR
T?locations=US
Adu-Bonsaffoh K, Oppong SA, Binlinla G and Obed SA.
Maternal deaths attributable to hypertensive
disorders in a tertiary hospital in Ghana. Int J
Gynaecol Obs 2013; 123(2): 110–113.
Antwi E, Klipstein-Grobusch K, Quansah Asare G, Koram
KA, Grobbee D and Agyepong IA. Measuring
regional and district variations in the incidence of
pregnancy-induced hypertension in Ghana:
challenges, opportunities and implications for
maternal and newborn health policy andprogrammes. Trop Med Int Heal 2016; 21(1): 93100.
Adu-Bonsaffoh K, Ntumy MY, Obed SA and Seffah JD.
Prevalence of hypertensive disorders in pregnancy at
Korle-Bu Teaching Hospital in Ghana. J Gynecol
Neonatal Biol 2017; 3(1): 8–13.
Dassah ET, Kusi-Mensah E, Morhe ESK and Odoi AT.
Maternal and perinatal outcomes among women with
hypertensive disorders in pregnancy in Kumasi,
Ghana. PLoS One 2019; 14(10): e0223478.
Drechsel KCE, Adu-Bonsaffoh K, Loohuis KMO,
Srofenyoh EK, Boateng D and Browne JL. Severe
preeclampsia adverse outcome triage (SPOT) studies
consortium. Maternal near-miss and mortality
associated with hypertensive disorders of pregnancy
remote from term: a multicenter observational study
in Ghana. AJOG Glob Rep 2022; 2(2): 100045.
Abalos E, Cuesta C, Grosso AL, Chou D and Say L. Global
and regional estimates of preeclampsia and
eclampsia: A systematic review. Eur J Obs. Gynecol
Reprod Biol 2013; 170(1): 1–7.
Long Q, Oladapo OT, Leathersich S, Vogel JP, Carroli G,
Lumbiganon P, Qureshi Z and Gülmezoglu AM.
WHO multicountry survey on maternal and newborn
health research network. Clinical practice patterns on
the use of magnesium sulfate for treatment of pre
eclampsia and eclampsia: a multi-country survey.
BJOG 2017; 124(12): 1883–1890.
Eddy KE, Vogel JP, Zahroh RI and Bohren MA. Factors
affecting use of magnesium sulphate for pre
eclampsia or eclampsia: A qualitative evidence
synthesis. BJOG 2022; 129: 379–391.
GSS. Ghana statistical service. Ghana 2021 population and
housing census general report volume 3A.
Populations of regions and districts 2021. Available
from:
https://statsghana.gov.gh/gssmain/fileUpload/pressr
elease/2021
PHC
General
Report
Vol
A_Population of Regions and Districts_181121.pdf
Republic of Ghana: Ministry of health, national drugs
program, standard treatment guidelines. 7 ed. Ghana
Yamens Press Ltd, 2017.
Chowa PE, Lin C, Goma F and South-Paul J. Hypertension
among women of child bearing age in Zambia. Med
J Zambia 2011; 38(3): 2011
Tesfa E, Nibret E, Gizaw ST, Zenebe Y, Mekonnen Z,
Assefa S, Melese M, Fentahun N and Munshea A.
Prevalence and determinants of hypertensive
disorders of pregnancy in Ethiopia: A systematic
review and meta-analysis. PLoS One 2020; 15(9):
e0239048.
Gemechu KS, Assefa N and Mengistie B. Prevalence of
hypertensive disorders of pregnancy and pregnancy
outcomes in Sub-Saharan Africa: A systematic
review and meta-analysis. Womens Health (Lond)
Azubuike A and Danjuma I.. Hypertension in pregnancy
among rural women in Katsina State, Nigeria. J.
basic clin. reprod. sci 2017; 6(1): 140–146.
Garanet F, Samadoulougou S, Baguiya A, Bonnechère B,
Millogo T, Degryse JM, Kirakoya-Samadoulougou F
and Kouanda S. Low prevalence of high blood
pressure in pregnant women in Burkina Faso: A
cross-sectional study. BMC Pregnancy Childbirth
; 22(1): 955.
Adongo PA, Atanga RA and Yakong VN. Demographic
characteristics of women that use traditional birth
attendants in Bongo District, Ghana. Eur J Midwifery
; 4(1).
Adatara P, Strumpher J and Ricks E. Exploring the reasons
why women prefer to give birth at home in rural
northern Ghana: A qualitative study. BMC
Pregnancy Childbirth 2020; 20(1): 500.
Chemeda WC, Gurmesa TS, Gedefa AG and
Woldasemayat LA. Factors associated with
hypertensive disorders among pregnant mothers
attending antenatal care services at public health
facilities in Gambella Town, Southwest Ethiopia: A
cross-sectional study. Int J Afr Nurs Sc 2022; 17:
Meazaw MW, Chojenta C, Muluneh MD and Loxton D.
Factors associated with hypertensive disorders of
pregnancy in sub-Saharan Africa: A systematic and
meta-analysis. PLoS One 2020; 15(8): e0237476.
Beyuo TK, Lawrence ER, Kobernik EK and Oppong SA.
Clinical presentation and predictors of eclampsia
among women with hypertensive disorders of
pregnancy in Ghana. Pregnancy Hypertens 2022; 30:
–176.
Moodley J and Ngene N. Maternal deaths due to eclampsia
in teenagers: Lessons from assessment of maternal
deaths in South Africa. Afr J Prim Heal. Care Fam
Med 2020; 12(1): a2305.
Dimitriadis E, Rolnik DL, Zhou W, Estrada-Gutierrez G,
Koga K, Francisco RPV, Whitehead C, Hyett J, da
Silva Costa F, Nicolaides K and Menkhorst E. Pre
eclampsia. Nat Rev Dis Primers 2023: 16; 9(1): 8.
Walle TA and Azagew A. Hypertensive disorder of
pregnancy prevalence and associated factors among
pregnant women attending ante natal care at Gondar
town health institutions, North West Ethiopia.
Pregnancy Hypertens 2019; 16: 79–84.
Lopian M, Kashani-Ligumsky L and Many A. A balancing
act: Navigating hypertensive disorders of pregnancy
at very advanced maternal age, from preconception
to postpartum. J Clin Med 2023; 12(14): 4701.
Harvey A, Montezano AC and Touyz R. Vascular biology
of ageing-Implications in hypertension. J Mol Cell
Cardiol 2015; 83: 112–121.
Luo ZC, An N, Xu HR, Larante A, Audibert F and FraserW. The effects and mechanisms of primiparity on the
risk of pre-eclampsia: a systematic review. Paediatr
Perinat Epidemiol 2007; Suppl 1: 36–45.
Bugri AA, Gumanga SK, Yamoah P, Frimpong EK and
Nlooto M. Prevalence of hypertensive disorders,
antihypertensive therapy and pregnancy outcomes
among pregnant women: A retrospective review of
cases at Tamale Teaching Hospital, Ghana. Int J Env.
Res Public 2023; 20(12): 6153.
Awaludin A, Rahayu C, Daud NAA and Zakiyah N.
Antihypertensive
medications
for
severe
hypertension in pregnancy: A systematic review and
meta-analysis. Healthcare 2022; 10(2): 325.
Smith P, Anthony J and Johanson R. Nifedipine in
pregnancy. BJOG 2000; 107(3): 299–307.
Cohan JA and Checcio L. Nifedipine in the management of
hypertensive emergencies: report of two cases and
review of the literature. Am J Emerg Med 1985; 3(6):
–530.
WHO. Recommendations on drug treatment for non-severe
hypertension in pregnancy. Geneva: World Health
Organization, Licence: CC BY-NC-SA 3.0 IGO,
Available
from:
https://www.ncbi.nlm.nih.gov/books/NBK561249/t
able/ch1.tab1/%0A
Fordjour F, Dassah ET, Mensah KB, Appiah-Kubi A,
Amoateng P, Buabeng KO and Darko KA.
Antihypertensives therapy and monitoring in pre
eclampsia: Role of the pharmacist. J Popul Ther Clin
Pharmac 2023; 30(17):354–367.
Oriji PC, Allagoa DO, Ubom AE, Kattey AK, Briggs DC,
Chika MN, Iloeje UN, Akanatei ID and Atemie G.
Hypertensive disorders in pregnancy at the Federal
Medical Centre, Yenagoa, South-South Nigeria: A 5
year review. Int J Res Med Sci 2021; 9(10): 2923
Hricik DE, Smith MC and Wright, J. Hypertension Secrets.
(Hanley & Belfus, Philadelphia), 2002.
WHO. Recommendations for prevention and treatment of
preeclampsia and eclampsia implications and
actions,
Available
from:
https://iris.who.int/bitstream/handle/10665/119627/
WHO_RHR_14.17_eng.pdf
Euser AG and Cipolla M. Magnesium sulfate for the
treatment of eclampsia: A brief review. Stroke 2009;
(4): 1169–1175.
APA. Lexicom Drug Information Handbook. (Wolters
Kluwer: USA), 2016
AHFS. American Hospital Formulary Service (AHFS)
Drug Information. American Society of Health
System Pharmacists, USA, 2003
USAID. Manual for procurement and supply of quality
assured MNCH commodities: Magnesium sulfate
injection, 500 mg/ml in 2-ml and 10-ml ampule
Available
from
https://www.ghsupplychain.org/sites/default/files/20
-11/MNCH
Commodities
Magnesium Sulfate.pdf
Procurement
Magnesium sulfate injection solution: HF acquisition Co
LLC DBA healthfirst. 2017. Available from:
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrug
Xsl.cfm?setid=945419b8-6184-f4f3-e053
a95a90a6236&type=display.
Roldán-Chicano MT, Rodríguez-Tello J, Cebrián-López R,
Moore JR and Del Mar García-López M. Adverse
effects of dorsogluteal intramuscular injection versus
ventrogluteal intramuscular injection: A systematic
review and meta-analysis. Nurs Open 2023; 10(9):
Allen LV and Ansel H. Ansel’s Pharmaceutical Dosage
Forms and Drug Delivery System. (Wolters Kluwer
Health, Philadelphia), 2013.
Babu JJ, Venkadalakshmi V, Dhandapani M and Chopra S.
Pain, drug leakage and inflammation associated with
intramuscular injections of magnesium sulfate in
preeclamptic women: A descriptive study. Nurs
Midwifery Res. J 2022; 18(1): 35–44.
Vallerand AH, Sanoski CA and Quiring C. Magnesium
Sulfate (Parenteral). In Davis’s Drug Guide.18th Ed.
F.A. Davis Company, 2023
PubCem. Bethesda (MD): National library of Medicine
(US), national center for biotechnology information.
PubChem compound summary for CID 24083,
magnesium sulfate, 2004. Available from:
https://pubchem.ncbi.nlm.nih.gov/compound/Magn
esium-Sulfate.
Beum R, Begum A, Johanson R, Ali MN and Akhter S. A
low dose (“Dhaka”) magnesium sulphate regime for
eclampsia. Acta Obs. Gynecol Scand 2001; 80(11):
–1002.
Beyuo K, Lawrence ER, Kobernik EK and Oppong SA. A
novel 12-hour versus 24-hour magnesium sulfate
regimen in the management of eclampsia and
preeclampsia in Ghana (MOPEP Study): A
randomized controlled trial. Int J Gynaecol Obs
; 159(2): 495–504.
Article Metrics
Abstract View
: 418 times
Download : 133 times
Refbacks
- There are currently no refbacks.




