Tear Film Functions and Intraocular Pressure Changes in Pregnancy

Waheed A Ibraheem, Anifat B Ibraheem, Aramide M Tijani, Samuel Oladejo, Susan Adepoju, Bukola Folohunso

Abstract

Pregnancy related ocular changes are diverse with varied clinical outcome. In a cross-sectional, descriptive case control study, we evaluated tear film functions and intraocular pressure during pregnancy and compared the results with non-pregnant women. A total of 270 participants including 165 healthy pregnant women and 105 non-pregnant who were free from systemic and pre-pregnancy eye diseases were investigated. Snellen‘s chart, fluorescein dye, No 41 Whatman filter paper, Perkin‘s tonometer were employed to assess visual acuity, tear break up time (TBUT), Schirmer‘s test (ST), intraocular pressure (IOP) on all subjects. The mean values for IOP (mmHg), TBUT (seconds) and Schirmer‘s reading (mm) were: 13.24±2.18, 25.05±9.30, 37.03±17.06 and 14.24±2.66, 22.10±10.81, 50.13±19.10 for cases and controls respectively. Schirmer‘s reading (SR) was significantly lower among pregnant women. Only age had a statistically significant association with the measured parameters. Our study revealed reduced SR during pregnancy. We suggest routine ocular assessment for pregnant women to forestall deleterious sequelae of dry eye. (Afr J Reprod Health 2015; 19[4]: 118-122).

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References

Garg P, Aggarwal P. Ocular changes in pregnancy. Nepal J Ophthalmol. 2012;4(1):150-61. 2. Omoti AE, Waziri-Erameh JM, Okeigbemen VW. A review of the changes in the ophthalmic and visual system in pregnancy. Afr J Reprod Health. 2008;12(3):185-96. 3. Pilas-Pomykalska M, Czajkowskii J, Oszukowski P. Ocular changes during pregnancy. Ginekol Pol. 2005;76(8):655-60.

Goldich Y, Cooper M, Barkana Y, Tovbin J, Lee Ovadia

K, Avni I, Zadok D. Ocular anterior segment changes in pregnancy. Journal of Cataract & Refractive Surgery. 2014;40(11):1868-71

Akar Y, Yucel I, Akar ME, Uner M, Trak B. Long-term

fluctuation of retinal sensitivity during pregnancy. Can J Ophthalmol. 2005;40(4):487-9 6. Skare TL, Gehlen ML, Silveira DMG, Uema MMDS. Pregnancy and lacrimal dysfunction. Rev. Bras. Ginecol. Obstet. 2012;34(4):170-4 7. Ding C, Lu M, Huang J. Changes of the ocular surface and aquaporins in the lacrimal glands of rabbits During pregnancy. Mol Vis. 2011;17:2847-55.

Goldich Y, Cooper M, Barkana Y, Tovbin J, Lee Ovadia

K, Avni I, Zadok D.Ocular anterior segment changes in pregnancy. J Cataract Refract Surg. 2014;40(11):1868-71.

Ataş M, Duru N, Ulusoy DM, Altınkaynak H, Duru Z,

Açmaz G etal. Evaluation of anterior segment parameters during and after pregnancy. Cont Lens Anterior Eye. 2014;37(6):447-50.

Ebeigbe JA, Ebeigbe PN, Ighoroje AD. Intraocular

pressure in pregnant and non-pregnant Nigerian women. Afr J Reprod Health. 2011;15(4):20-3 11. Pilas-Pomykalska M, Luczak M, Czajkowski J, Woznjak P, Oszwkowski. Changes in intra ocular pressure during pregnancy. P Klin Oozna. 2004;106(1-2): 238-9. 12. Ziai N, Ory SJ, Khan AR, Brubaker RF. ß -HCG, progesterone and aqueous dynamics during pregnancy. Arch Ophthalmol. 1994;112(6):801-6. 13. Pitta Paramjyothi, A.N.R. Lakshmi, D. Surekha. Physiological changes of intraocular pressure (IOP) in the second and third trimesters of normal Pregnancy Journal of Clinical and Diagnostic Research. 2011;5(5):1043-5. 14. Sears ML, Mead A. A major pathway for the regulation of intraocular pressure. Int Ophthalmol Clin. 1983;6:201-5. 15. Phillips CI, Gore SM. Ocular hypotensive effect of late pregnancy with and without high blood pressure. Br J Ophthalmol. 1985;69(2):117-119. 16. Ch EY, Moon JI. Intraocular pressure change in the pregnant glaucoma or ocular hypertension patients and normal women. Korean J Ophthalmol. 2004;45:1880

Wong J, Ding C, Yiu S, Smith R, Goodwin T, Schechter

JE. An epidemiological study of pregnancy and dry eye. Ocul Surf. 2004;3:S127.

Priori R, Medda E, Conti F. Risk factors for Sjogren‘s

syndrome: an Italian case-control study. IX International Symposium on Sjogren‘s Syndrome; Washington, DC. April 27–29, 2006; p. 64.

Priori R, Medda E, Conti F, Cassarà EA, Sabbadini MG,

Antonioli CM, et al. Risk factors for Sjögren‘s syndrome: a case-control study. Clin Exp Rheumatol. 2007;25:378–384.

Ding C, Chang N, Fong YC, Wang Y, Trousdale MD,

Mircheff AK, et al. Interacting influences of pregnancy and corneal injury on rabbit lacrimal gland immunoarchitecture and function. Invest Ophthalmol Vis Sci. 2006;47:1368–75. 21. Duarte MCB, NT Pinto, Moreira H, Moreira ATR, Wasilewski D. Total testosterone level in postmenopausal women with dry eye. Arq Bras Oftalmol.2007;70(3):465-9. 22. Kanova N, Bicikova M. Hyperandrogenic states in pregnancy. Physiol Res 2011;60(2):243-52. 23. MA Rivarola, MG Forest, Migeon CJ. Testosterone, androstenedione and dehydroepiandrosterone in plasma During pregnancy and at delivery: concentration and protein binding. J Clin Endocrinol Metab. 1968;28(1):34-40. 24. Choi JR, Levine D, Finberg H. Luteoma of pregnancy: sonographic findings in two cases. J Ultrasound Med2000;19(12):877-81.

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