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Effectiveness of continuous renal replacement therapy and hemoperfusion in treatment of acute severe organophosphorus pesticide poisoning

Xiaorong Cheng(1), Haiyang Yang(2), Jun Wu(3), Li Wang(4), Tingting Wu(5), Yuhong Chen(6),


(1) Department of Emergency Intensive Care Unit, Nangjing First Hospital, Nangjing Medical University, Nangjing, Jiangsu 210014, China
(2) Department of Emergency Intensive Care Unit, Nangjing First Hospital, Nangjing Medical University, Nangjing, Jiangsu 210014, China
(3) Department of Emergency Intensive Care Unit, Nangjing First Hospital, Nangjing Medical University, Nangjing, Jiangsu 210014, China
(4) Department of Emergency Intensive Care Unit, Nangjing First Hospital, Nangjing Medical University, Nangjing, Jiangsu 210014, China
(5) Department of Emergency Intensive Care Unit, Nangjing First Hospital, Nangjing Medical University, Nangjing, Jiangsu 210014, China
(6) Department of Nursing, Nangjing First Hospital, Nangjing Medical University, Nangjing, Jiangsu 210014, China
Corresponding Author

Abstract


This study aimed to investigate the effectiveness of continuous renal replacement therapy and hemoperfusion in acute severe organophosphorus pesticide poisoning patients. Fifty-eight acute severe organophosphorus pesticide poisoning patients who accepted therapy in Nangjing First Hospital, Nangjing Medical University from January 2018 to December 2022 were chosen as the study participants. They were randomly divided into a control group and a research group. Both groups received conventional treatment, while the research group received continuous renal replacement therapy combined with hemoperfusion therapy. Relative to the control group, the research group had higher total effectiveness rate, shorter coma time, cholinase recovery time, reduced stay in intensive care unit, less atropine dosage, lower levels of inflammatory factors and lower sequential organ failure assessment scores. Our study suggests that continuous renal replacement therapy combined with hemoperfusion can improve the clinical therapeutic effect in patients with acute severe organophosphorus pesticide poisoning, effectively control the inflammatory response, and shorten the clinical rescue and treatment time of patients.

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