Effect of Antimalarial Drugs and Malaria Infection on Oxidative Stress in Pregnant Women
), Odaibo A.B(2), Ademowo O.G(3),
(1)
(2)
(3)
Corresponding Author
Abstract
This work studied the effect of malaria infection and antimalarial drugs on oxidative stress in 259 pregnant and nonpregnant women at Ade-Oyo hospital, Ibadan, Nigeria. Oxidative stress was determined by measuring serum lipid peroxidation, ascorbic acid, and reduced glutathione (GSH) levels using spectrophotometer. The results showed that mean lipid peroxidation was significantly higher (p<0.05) in malaria positive than malaria negative women, while GSH and ascorbic acid levels were significantly (p<0.05) reduced. The parasite density was significantly reduced in patients who had taken antimalarial drugs relative to those without. While mean ascorbic acid and GSH levels were significantly reduced in those who had taken drugs as compared with those without drugs, the lipid peroxidation level was significantly higher in them. The increase in lipid peroxidation and decrease in GSH and ascorbic acid levels in women who were malaria positive and in those who had taken drugs is indicative of oxidative stress. (Afr. J. Reprod. Health 2010; 14[3]: 209-212).
Résumé
Effet des médicaments antipaludiques et l’infection causée par le paludisme sur le stress oxydatif chez les femmes enceintes. Cette étude a examiné l’effet de l’infection causée par le paludisme et des médicaments antipaludiques sur le stress oxydatif chez 250 femmes enceintes et non enceintes à l’hôpital Adeoyo à Ibadan, Nigéria. Le stress oxydatif a été déterminé en mesurant la peroxydation du lipide sérique, l’acide ascorbique et les niveaux réduits du glutathion (GSH) à l’aide d’un spectrophotomètre. Les résultats ont montré que la peroxydation lipide moyen a été élevée de manière significative (p<0,05) chez les femmes dont l’analyse pour déterminer la présence du paludisme a été positive par rapport à celles dont l’analyse a été négative, alors que les niveaux du GSH et l’acide ascorbique ont été réduits de manière significative (p<0,05). La densité parasitaire a été réduite de manière significative chez les patientes qui avaient pris des médicaments antipaludiques par rapport à celles qui n’en avaient pas pris. Alors que les niveaux de l’acide ascorbique et du GSH ont été réduits de manière significative par rapport à celles qui n’avaient pas pris des médicaments, le niveau de la peroxydation a été beaucoup plus élevé chez elles. L’augmentation dans la peroxydation lipide et la réduction dans le GSH et dans les niveaux de l’acide ascorbique chez les femmes dont l’analyse du paludisme a été positive et chez celles qui avaient pris des médicaments est une indication du stress oxydatif (Afr. J. Reprod. Health 2010; 14[3]: 209-212).
Key words: Pregnant women, malaria, lipid peroxidation, reduced glutathione, Ascorbic acid.
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