Analysis of maternal serum vitamin D concentrations at birth in women presenting with spontaneous preterm birth: A case-control study
), Alfred Maluwa(2), Augustine Choko(3), Jon Odland(4),
(1) Department of Obstetrics and Gynaecology, University of Malawi, College of Medicine, Lilongwe, Malawi; Kamuzu Central Hospital, Lilongwe, Malawi; Bwaila Hospital, Lilongwe,
(2) Malawi University of Science and Technology, Limbe
(3) Malawi Liverpool Wellcome Trust Clinical Research Programme, TB/HIV Department, Blantyre, Malawi
(4) The Norwegian University of Science and Technology, Trondheim, Norway4; School of Health Systems and Public Health, University of Pretoria, South Africa
Corresponding Author
Abstract
Vitamin D is a potent immune system modulator; its deficiency correlates with increased susceptibility to infections. We evaluated the status of maternal serum vitamin D in women with spontaneous preterm birth. In this case-control study, the maternal serum concentration of vitamin D (25OH D) was measured in 95 women delivering preterm and 92 women having a term birth. Vitamin D sufficiency was found in 79% of the mothers who delivered preterm and 80.4% of the mothers who had term birth (p=0.822). There was a negative correlation between maternal serum concentration of 25 Hydroxyvitamin D and maternal age in the preterm birth group (p=0.043). In conclusion, there was no difference in maternal serum concentrations of 25 Hydroxyvitamin D between women delivering preterm compared to those having term birth. Maternal serum concentration of 25 Hydroxyvitamin D is not associated with occurrence of preterm birth. (Afr J Reprod Health 2021; 25[2]: 103-109).
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