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Ovarian Cancer in Ghana, a 10 Year Histopathological Review of Cases at Korle Bu Teaching Hospital

Patrick K Akakpo(1), Leonard Derkyi-Kwarteng(2), Richard K Gyasi(3), Solomon E Quayson(4), Jehoram T Anim(5),


(1) Department of Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast Teaching Hospital, Cape Coast, Ghana
(2) Department of Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast Teaching Hospital, Cape Coast, Ghana
(3) Department of Pathology, College of Health Sciences, University of Ghana Medical School Korle-Bu Teaching Hospital, Accra, Ghana
(4) Department of Pathology, College of Health Sciences, University of Ghana Medical School Korle-Bu Teaching Hospital, Accra, Ghana
(5) Department of Pathology, College of Health Sciences, University of Ghana Medical School Korle-Bu Teaching Hospital, Accra, Ghana
Corresponding Author

Abstract


To determine the histopathological types, age distribution, presenting signs and symptoms of ovarian cancers diagnosed at the Korle-Bu Teaching Hospital, Ghana. All histopathology slides and request cards of ovarian cancers diagnosed over a ten-year period (2001 to 2010) were reviewed and the cancers classified according to the World Health Organization 1999 classification. Biographical and clinical data of the patients were collected and results entered into Epi-info to determine the frequency, age distribution and clinical presentation of the various types of ovarian cancer. There were 192(27.2%) ovarian cancers out of 706 ovarian tumours. Epithelial cancers were the most common: 100 (52.1%), followed by sex cord stromal cancers 66 (34.4%). Majority of epithelial cancers were serous adenocarcinomas (71/100) while most sex cord stromal cancers were adult granulosa cell tumours 46 (69.7%). The mean age of patients with adenocarcinoma was 49 years while that of the 46 adult granulosa cell tumours was 46.5years. Patients present with varying combinations of symptoms and signs and ovarian cancers present at an earlier age compared to other populations, with the age of presentation being slightly lower for sex cord stromal cancers compared to adenocarcinomas. There are no specific symptoms or signs associated with ovarian cancer at presentation, to assist with diagnosis.

References


Wiredu E K, Armah B H; Cancer mortality patterns

in Ghana: a 10-year review of autopsies and hospital mortality. BMC Public Health 2006, 6:159.

Nkyekyer K; Pattern of gynaecological cancers in

Ghana. East Afr Med J. 2000; 77:534-38.

M O Buhari, B A Ojo, M A Ijaiya, P A Aboyeji.

Ovarian Cancers in Ilorin, Nigeria-a Review of Over 80 Cases. Nig Quart Journ of Hosp Med 2005 15: 127-30 4. Obed JY, Khalil MI, Ekanem ED Histological types of ovarian tumours as seen in an African teaching hospital in north-eastern Nigeria. J Obstet Gynaecol. 1999;19:526-28.

Lee-Jones L. Ovarian Tumours: An overview. Atlas of

Genetics Cytogenetics, Oncologic Haematology. December 2000. Document available on the internet at: http://AtlasGeneticsOncology.org/Tumors/

OvarianTumOverviewID5231.html. 6. Moorman P G, Palmieri R T, Akushevich L, Berchuck A, Schildkraut J M. Ovarian Cancer Risk Factors in

Akakpo et al. Ovarian Cancer, Ghana

African Journal of Reproductive Health December 2015; 19 (4): 106

African-American and White Women. Amer J of Epidemiol 2009; published online at; aje.oxfordjournals.org/cgi/content/full/kwp176v1

Vanderpuye V, Yarney J. Ovarian cancer; an analysis of

forty four patients at the National Radiotherapy Centre, Accra, Ghana. West Afr J Med. 2007; 26:93-6

Iyoke CA1, Ifeadike CO, Nnebue CC, Nkwo PO,

Ezugwu EC, Edosuyi L, Onah LN, Onah HE1 Okafor O. A Ten-Year Review of Ovarian Cancer in Enugu, South East Nigeria Afrimedic Journal 2011;2:8-12

Ovary, Tumours In Juan Rosai (editor). Rosai and

Ackerman‘s surgical pathology 9th edition (China): Mosby, 2004: 1659-1709.

Mondal SK, Banyopadhyah R, Nag DR, Roychowdhury

S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India. J Can Res Ther 2011;7:433-37

Khan A, Sultana K Presenting signs and symptoms of ovarian cancer at a tertiary care hospital. J Pak Med Assoc. 2010; 60:260-2.


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