Office Microlaparoscopic intrafallopian transfer of day one Zygote Versus day three embryo transfer after previous failed ICSI trials
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Abstract
The objective of the study was to investigate whether transferring zygotes on day 1 would result in similar pregnancy rates compared to transferring cleavage stage embryos on day 3 in a prospective randomized trial, using the office microlaparoscopic procedure. Patients undergoing IVF/ICSI treatments were randomized to either day 1 or day 3 transfers after previous failed ICSI trials due to failed implantation. The primary outcome measure was pregnancy rate. Pregnancy rates were higher in day 3 group (55/131, 42%) when compared to day 1 (34/123, 28%, P = 0.024). Similarly, implantation rates were higher in day 3 group (P= 0.03). There were more cycles with cryopreservation in the day 1 group (P < 0.001). Embryo quality on day 3 was similar between pattern 0 and nonpattern 0 zygotes. Day 3 embryo transfers result in better pregnancy and implantation rates compared to day 1 zygote transfers.
RésuméCette étude avait pour objectif d'examiner si le transfert des zygotes dès le premier jour aboutira aux taux de grossesse similaire par rapport au transfert des embryons du moment de segmentation le troisième jour dans un essai prospectif et randomisé à l'aide de la procédure micro-laparoscopique de bureau. Les patientes qui subissent des traitements de FIV/ISIC ont été randomisées en transferts du premier jour ou du troisième jour. Le taux de grossesse était plus élevé chez le groupe du troisième jour (55/131, 42%) par rapport au groupe du premier jour (34/123, 28%, P= 0,024). De la même manière, le taux d'implantation était plus élevé chez le groupe du troisième jour (P=0,03). Il y avait plus de cycles qui avaient la cryopréservation chez le groupe du premier jour (P<0,001). La qualité de l'embryon le troisième jour était pareille parmi les zygotes du modèle 0 et les zygotes 0 sans modèle. Les transferts des embryons du troisième jour aboutissent à de meilleurs taux de grossesse et d'implantation par rapport à des transferts des zygotes du premier jour.
Key words: embryo transfer/pronuclear scoring/zygote
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