The association between the prevalence of HIV infection and ectopic pregnancy

Mokoena M. Mohosho(1),


(1) Department of Obstetrics & Gynaecology, Ladysmith Provincial Hospital, Kwazulu Natal, South Africa
Corresponding Author

Abstract


Women infected with the human immunodeficient virus have a higher risk of pelvic inflammatory disease, which could lead to development of ectopic pregnancy due to fallopian tubal pathology. Due to short pregnancy period, women with ectopic pregnancy unlikely complete the antenatal screening, which includes HIV tests. Therefore, it is postulated that unscreened HIV infection prevalence in women with ectopic pregnancy diagnosis could be significantly higher than in women with normal intrauterine pregnancy (IUP). The aim of the present retrospective cross-sectional study was to determine the association between ectopic pregnancy and HIV infection in KwaZulu Natal Province hospital setting, between 2016 and 2017. 5427 pregnant women with normal pregnancies formed the intrauterine pregnancy (IUP) cohort, while 83 patients were part of the ectopic pregnancy cohort. The statistical HIV prevalence was significantly higher in the ectopic pregnancy cohort (56.63% vs 39.4%, P-value of 0.001). In addition, HIV prevalence in the ectopic pregnancy cohort was analyzed per age group, and it was found to be higher in the 25-34 years age group (88.3%) than the 16-24 (43.3%) and 35-42 (60%) years age groups. This study highlights the significance of conducting a full antenatal screening programme in patients who present with ectopic pregnancy, to improve the rate of HIV infection testing and treatment in women who present with ectopic pregnancy. (Afr J Reprod Health 2023; 27 [2]: 87-91).

References


Hendriks E, Rosenberg R and Prine L. Ectopic Pregnancy:

Diagnosis and Management. Am Fam Physician

;101(10):599–606.

Hendriks E, MacNaughton H and MacKenzie MC. First

Trimester Bleeding: Evaluation and Management. Am

Fam Physician 2019;99(3):166–74.

Charvériat A and Fritel X. [Diagnosis of pelvic inflammatory

disease: Clinical, paraclinical, imaging and

laparoscopy criteria. CNGOF and SPILF Pelvic

Inflammatory Diseases Guidelines]. Gynecol Obstet

Fertil Senol 2019;47(5):404–8.

https://doi.org/10.1016/J.GOFS.2019.03.010.

Scibetta EW and Han CS. Ultrasound in Early Pregnancy:

Viability, Unknown Locations, and Ectopic

Pregnancies. Obstet Gynecol Clin North Am

;46(4):783–95.

https://doi.org/10.1016/J.OGC.2019.07.013.

Pillai DAS and RS DCS. Incidence, diagnosis and

management of ectopic pregnancies: A review. Int J

Clin Obstet Gynaecol 2020;4(5):220–3.

https://doi.org/10.33545/GYNAE.2020.V4.I5D.708.

Glenda E Gray, and James A McIntyre. Effect of HIV on

women . AIDS Read 2006;16(7):365–8.

Pongsuthirak P, Vutyavanich T, Apichartpiyakul C,

Vithayasai V and Piromiertamorn W. Seroprevalence

of Human Immunodeficiency Virus in Patients with

Ectopic Pregnancies. Thai J Obstet Gynaecol

:123–9.

World Health Organization. HIV/AIDS. Fact Sheet 360.

Geneva: 2013.

Mugauri HD, Karakadzai M, Mugurungi O, Welfare C,

Chirenda J and Tshimanga M. Exploring HIV Testing Service Models for Enhanced Positivity Yield in

Southern Africa, 2022: A Systematic Review 2022.

https://doi.org/10.21203/rs.3.rs-1497896/v2.

South African Department of Health. Saving Mothers.

Annual report. 2017.

Woldesenbet SA, Kufa-Chakezha T, Lombard C, Manda S,

Cheyip M, Ayalew K, Chirombo B, Barron P, Diallo

K, Parekh B and Puren A. The 2019 National

Antenatal Sentinel HIV Survey, South Africa. South

Africa: 2021.

Mohosho MM. HIV prevalence in patients with cervical

carcinoma: A cohort study at a secondary hospital in

South Africa. Medicine (Baltimore)

;100(35):e27030.

https://doi.org/10.1097/MD.0000000000027030.

Consolidated guidelines on HIV testing services (2015)

https://www.who.int/publications/i/item/9789241508

(accessed September 11, 2022).

Maternal mortality: Levels and trends 2000 to 2017 n.d.

https://www.who.int/publications/i/item/9789241516

(accessed September 14, 2022).

Tenore JL. Ectopic Pregnancy. Am Fam Physician

;61(4):1080–8.

Chouinard M, Mayrand MH, Ayoub A, Healy-Profitós J and

Auger N. Ectopic pregnancy and outcomes of future

intrauterine pregnancy. Fertil Steril 2019;112(1):112–

https://doi.org/10.1016/j.fertnstert.2019.03.019.

Amoko DH and Buga GA. Clinical presentation of ectopic

pregnancy in Transkei, South Africa. East Afr Med J

;72(12):770–3


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