Correlates and reproductive consequences of consanguinity in six Egyptian governorates

Wafaa M. Hussein(1), Maha M. El-Gaafary(2), Ghada O. Wassif(3), Maha M. Wahdan(4), Dalia G. Sos(5), Sally A. Hakim(6), Amany M. Abdelhafez(7), Mohamed Y. El-Awady(8), Mervat H. Rady(9), Tarek T. Amin(10), Wagida A. Anwar(11),


(1) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(2) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(3) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(4) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(5) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(6) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(7) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(8) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(9) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
(10) The National Population Council, Egypt; College of Medicine, Cairo University, Egypt
(11) Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Corresponding Author

Abstract


This study aimed to explore some correlates and potential reproductive consequences of consanguinity. We analysed data for 8515 ever-married women aged 15-49 derived from a household survey conducted in 2017 in six governorates. The prevalence of consanguineous marriage was 35.9%. The odds (OR (95%CI)) of consanguinity were higher in rural southern governorates (3.68 (3.03-4.46)), with less than secondary education (1.55 (1.42-1.7)), with unemployment (1.74(1.48-2.04)) and in the lowest wealth quintile (3.09 (2.66-3.6)). After adjusting for residence, education, wealth, age at marriage and the number of children; the OR (95%CI) for spontaneous abortion and still births with consanguinity were 1.31 (1.09-1.59) and 1.63 (1.18-2.25) respectively. Consanguinity remains highly prevalent in Egypt especially in rural southern governorates. Women empowerment in terms of attaining higher education and employment may reduce the problem. Consanguinity appears to be associated with adverse reproductive outcomes including spontaneous abortion and still birth. (Afr J Reprod Health 2022; 26[12s]: 48-56).

References


Akrami SM. Genetics of consanguineous marriage: Impact

and importance of counseling. Journal of pediatric genetics. 2012/12//undefined 2012;1(4):217-220.

doi:10.3233/PGE-12034

Darr A, Small N, Ahmad WIU, Atkin K, Corry P and Modell

B. Addressing key issues in the consanguinity-related

risk of autosomal recessive disorders in

consanguineous communities: lessons from a

qualitative study of British Pakistanis. Journal of

community genetics. 2016/01//undefined

;7(1):65-79. doi:10.1007/s12687-015-0252-2

Bittles AH. Consanguinity, Genetic Drift, and Genetic

Diseases in Populations with Reduced Numbers of

Founders. In: Speicher MR, Motulsky AG,

Antonarakis SE, eds. Vogel and Motulsky's Human

Genetics. Springer Berlin Heidelberg; 2010:507-528.

Bittles AH, Black ML. The impact of consanguinity on

neonatal and infant health. Early human

development. 2010/11//undefined 2010;86(11):737-

doi:10.1016/j.earlhumdev.2010.08.003

Tadmouri GO, Nair P, Obeid T, Al Ali MT, Al Khaja N and

Hamamy HA. Consanguinity and reproductive health

among Arabs. Reproductive health. 2009/10/08/

;6:17. doi:10.1186/1742-4755-6-17

Modell B and Darr A. Science and society: genetic

counselling and customary consanguineous marriage.

Nature reviews Genetics. 2002/03//undefined

;3(3):225-229. doi:10.1038/nrg754

Bittles AH. Consanguinity in Context. Cambridge Studies in

Biological and Evolutionary Anthropology.

Cambridge University Press; 2012.

Bittles AH and Black ML. Consanguinity, human evolution,

and complex diseases. Proceedings of the National

Academy of Sciences. 2010/01/26/ 2010;107(suppl

:1779. doi:10.1073/pnas.0906079106

Abbas HA and Yunis K. The effect of consanguinity on

neonatal outcomes and health. Human heredity. 2014

;77(1-4):87-92. doi:10.1159/000362125

Abrar S, Safdar W, Hanif M and Shujaat N. Pregnancy

Outcomes Of Consanguinity Among Antenatal

Patients Attending Combined Military Hospital

Quetta, Pakistan. Journal of Ayub Medical College,

Abbottabad : JAMC. 2018/09//Jul- undefined

;30(3):423-427.

Islam MM, Dorvlo AS and Al-Qasmi AM. The pattern of

female nuptiality in oman. Sultan Qaboos University

medical journal. 2013/02//undefined 2013;13(1):32-

doi:10.12816/0003193

Romdhane L, Ben Halim N, Rejeb I, Kefi R, Bouyacoub Y,

Ben Rekaya M, Messai H, Messaoud O, Riahi Z,

Bonnet C, Ben Rhouma F, Nagara M, Petit C,

McElreavey K, Romeo G and Abdelhak S. Specific

aspects of consanguinity: some examples from the

Tunisian population. Human heredity. 2014

;77(1-4):167-174. doi:10.1159/000362167

Warsy AS, Al-Jaser MH, Albdass A, Al-Daihan S and

Alanazi M. Is consanguinity prevalence decreasing in

Saudis?: A study in two generations. African health

sciences. 2014/06//undefined 2014;14(2):314-321.

doi:10.4314/ahs.v14i2.5

Ministry of health and population[Egypt], El-Zanaty and

associates[Egypt], ICF International. Egypt

Demographic and Health Survey 2014. 2015.

Yunis K, Rafei RE and Mumtaz G. International

Perspectives: Consanguinity: Perinatal Outcomes and

Prevention – A View from the Middle East.

NeoReviews. 2008/02/01/ 2008;9(2):e59-e65.

doi:10.1542/neo.9-2-e59

Bittles AH. Consanguineous marriage and childhood health.

Developmental medicine and child neurology.

/08//undefined 2003;45(8):571-576.

doi:10.1017/s001216220300104x

Na'amnih W, Romano-Zelekha O, Kabaha A, Rubin LP,

Bilenko N, Jaber L, Honovich M and Shohat T.

Prevalence of consanguineous marriages and

associated factors among Israeli Bedouins. Journal of

community genetics. 2014/10// 2014;5(4):395-398.

doi:10.1007/s12687-014-0188-y

Benson JWT. Recessive disorders and consanguineous

marriage. BMJ (Clinical research ed). 2005/12/17/

;331(7530):1475-1475.

doi:10.1136/bmj.331.7530.1475

Hamamy HA, Masri AT, Al-Hadidy AM and Ajlouni KM.

Consanguinity and genetic disorders. Profile from

Jordan. Saudi medical journal. 2007/07//undefined

;28(7):1015-1017.

Romeo G and Bittles AH. Consanguinity in the

contemporary world. Human heredity. 2014

;77(1-4):6-9. doi:10.1159/000363352

Yunis K, Mumtaz G, Bitar F, Chamseddine F, Kassar M,

Rashkidi J, Makhoul G and Tamim H.

Consanguineous marriage and congenital heart

defects: a case-control study in the neonatal period.

American journal of medical genetics Part A.

/07/15/ 2006;140(14):1524-1530.

doi:10.1002/ajmg.a.31309

Al-Gazali L and Ali BR. Mutations of a country: a mutation

review of single gene disorders in the United Arab

Emirates (UAE). Human mutation.

/05//undefined 2010;31(5):505-520.

doi:10.1002/humu.21232

Corry PC. Consanguinity and prevalence patterns of

inherited disease in the UK Pakistani community.

Human heredity. 2014 2014;77(1-4):207-216.

doi:10.1159/000362598

Sheridan E, Wright J, Small N, Corry PC, Oddie S, Whibley

C, Petherick ES, Malik T, Pawson N, McKinney PA

and Parslow RC. Risk factors for congenital anomaly

in a multiethnic birth cohort: an analysis of the Born

in Bradford study. Lancet (London, England).

/10/19/ 2013;382(9901):1350-1359.

doi:10.1016/S0140-6736(13)61132-0

Anwar WA, Khyatti M and Hemminki K. Consanguinity

and genetic diseases in North Africa and immigrants

to Europe. European journal of public health.

/08//undefined 2014;24 Suppl 1:57-63.

doi:10.1093/eurpub/cku104

Oniya O, Neves K, Ahmed B and Konje JC. A review of the

reproductive consequences of consanguinity.

European journal of obstetrics, gynecology, and

reproductive biology. 2019/01//undefined

;232:87-96. doi:10.1016/j.ejogrb.2018.10.042

Chaman R, Gholami Taramsari M, Khosravi A, Amiri M,

Holakouie Naieni K and Yunesian M. Consanguinity and neonatal death: a nested case-control study.

Journal of family & reproductive health. 2014/12//

;8(4):189-193.

Kerkeni E, Monastiri K, Saket B, Guediche MN and Ben

Cheikh H. Interplay of socio-economic factors,

consanguinity, fertility, and offspring mortality in

Monastir, Tunisia. Croatian medical journal.

/10//undefined 2007;48(5):701-707.

Khayat RG and Saxena PC. Consanguinity and its effect on

fertility and infant and child mortality in Egypt. 2004:

Maghsoudlou S, Cnattingius S, Aarabi M, Montgomery

SM, Semnani S, Stephansson O, Wikström AK and

Bahmanyar S.. Consanguineous marriage,

prepregnancy maternal characteristics and stillbirth

risk: a population-based case–control study. Acta

Obstetricia et Gynecologica Scandinavica.

/10/01/ 2015;94(10):1095-1101.

doi:10.1111/aogs.12699

Assaf S, Khawaja M, DeJong J, Mahfoud Z and Yunis K.

Consanguinity and reproductive wastage in the

Palestinian Territories. Paediatric and perinatal

epidemiology. 2009/03//undefined 2009;23(2):107-

doi:10.1111/j.1365-3016.2008.00988.x

Islam MM. Effects of consanguineous marriage on

reproductive behaviour, adverse pregnancy outcomes

and offspring mortality in Oman. Annals of human

biology. 2013/05//undefined 2013;40(3):243-255.

doi:10.3109/03014460.2012.760649

Mokhtar MM and Abdel-Fattah MM. Consanguinity and

advanced maternal age as risk factors for

reproductive losses in Alexandria, Egypt. European

journal of epidemiology. 2001 2001;17(6):559-565.

doi:10.1023/a:1014567800950


Full Text: PDF

Article Metrics

Abstract View : 1006 times
PDF Download : 316 times

Refbacks

  • There are currently no refbacks.