Lassa fever in pregnancy: Report of two maternal deaths in a tertiary center in the middle-belt region of Nigeria
), Olayinka Amode(2), Emmanuel H. Gbejegbe(3), Abdulkarim O Musa(4), Aisha N Adamu(5), Austin Ojotule(6), Ashiru A. Ladan(7), Ahuoiza A. Ojiah(8), Abimbola Adesanya(9), Gboyega M. Olarinoye(10), Oluwamayowa D. Kassim(11), Jude O. Nnorom(12), Obinna C. Onwufor(13),
(1) Department of Obstetrics and Gynaecology, Federal Medical Center, Lokoja,
(2) Department of Obstetrics and Gynaecology, Federal Medical Center, Lokoja, Nigeria
(3) Department of Obstetrics and Gynaecology, Federal Medical Center, Lokoja, Nigeria
(4) Department of Obstetrics and Gynaecology, Federal Medical Center, Lokoja, Nigeria
(5) Department of Obstetrics and Gynaecology, Federal Medical Center, Birnin Kebbi, Nigeria
(6) Department of Community Health, Kogi State Ministry of Health, Lokoja, Nigeria
(7) Department of Obstetrics and Gynaecology, Federal Medical Center, Birnin Kebbi, Nigeria
(8) Department of Community Health, Federal Medical Center, Lokoja, Nigeria
(9) Department of Community Health, Federal Medical Center, Lokoja, Nigeria
(10) Dermatology/Infectious Disease Unit, Department of Medicine, Federal Medical Center, Lokoja, Nigeria
(11) Department of Haematology, Federal Medical Center, Lokoja, Nigeria
(12) Department of Obstetrics and Gynaecology, Federal Medical Center, Lokoja, Nigeria
(13) Department of Obstetrics and Gynaecology, Federal Medical Center, Lokoja, Nigeria
Corresponding Author
Abstract
Lassa fever is endemic in West Africa, with an estimated 300,000 to 500,000 infections occurring annually and approximately 5,000 deaths. Two Lassa fever cases in pregnancy with maternal and fetal complications were presented. The age range was 20 to 30 years and the range of parity was 1 to 3. The duration of symptoms was 13 to 14days. Clinical presentation and complications common to the two cases were fever, abnormal bleeding, cough/sore throat, anaemia, IUFD/Stillbirth, and maternal deaths. Others are vomiting, restlessness/confusion, hypotension and thrombocytopaenia. Major challenges encountered are late presentation, delay in confirming diagnosis and instituting definitive treatment, limited facility, and the impact of traditional and religious factors in safe burial for Lassa fever cases. In resource-constrained settings; diagnosis, treatment and surveillance for Lassa fever may be challenging. Early clinical suspicion and appropriate case management are critical for good reproductive outcome. (Afr J Reprod Health 2022; 26[2]: 137-143).
References
Asogun DA, Adomeh DI, Ehimuan J, Odia I, Hass M, Gabriel M, Olschlager S, Becker-Ziaja B, Folarin O, Phelan E, Ehiane PE, Ifeh VE, Uyigue EA, Oladapo YT, Muoebonam EB, Osunde O, Dongo A, Okokhere PO, Okogbeni SA, Momoh M, Alikah SO, Akhuemokhan OC, Imomeh P, Odike MAC, Gire S, Andersen K, Sabeti PC, Happi CT, Akpede GO and Gunther S. Molecular diagnostics for Lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. PLoS Negl Trop Dis 2012: 6(9): e1839.https://doi.org/10.1371/journal.pntd.0001839
World Health Organization, “Lassa fever. Fact sheet” (2017), http://www.who.int/news-room/fact-sheets/detail/lassa-fever.
Centers for Disease Control and Prevention (CDC) Lassa Fever, “CDC fact sheet” CDC (2019), http://www.cdc.gov/vhf/lassa/
Ogbu O, Ajuluchukwu E and Uneke CJ. Lassa fever in West African sub-region: an overview. J Vector Borne Dis. 2007;44(1):1 – 11. PMID:17378212
Branco LM, Boisen ML, Andersen KG, Grove JN, Moses LM, Muncy IJ, Henderson LA, Schieffellin JS, Robinson JE, Bangura JJ, Grant DS, Raabe VN, Fonnie M, Sabeti PC and Garry RF. Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report. Virol J 2011; 8: 404.https://doi.org/10.1186/1743-422X-8-404
Price ME, Fisher‐Hoch SP, Craven RB and McCormick JB: A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy. BMJ 1988; 297: 584 – 587.doi:10.1136/bmj.297.6648.584
Agboeze J, Nwali MI, Nwakpakpa E, Ogah OE, Onoh R, Eze J, Ukaegbe C, Ajayi N, Nnadozie UU, Orji ML, Ojide KC, Unigwe SU, Chika-Igwenyi N, Nwidi DU, Clement CU, Kalombo C, Makwe C and Tshiang J. Lassa fever in pregnancy with a positive maternal and fetal outcome: A case report. IJID;
(89): 84 – 86.doi:10.1016/j.ijid.2019.08.023
Kayem ND, Benson C, Aye CYL, Barker S, Tome M, Kennedy S, Ariana P and Horby P. Lassa fever in pregnancy: A systematic review and meta-analysis. Trans R Soc Trop Med Hyg 2020; 114: 385 – 396.doi:10.1093/trstmh/traa011.
Nigeria Centre for Disease Control (NCDC): National Guidelines for Lassa fever case management November 2018: 1 – 58. https://ncdc.gov.ng>protocols.
Eberhardt KA, Mishlinger J, Jordan S, Groger M, Gunther S and Ramharter M. Rivabirin for the treatment of Lassa fever: A Systematic Review and Meta-Analysis. IJID; 2019(87): 15 – 20. https://doi.org/10.1016/j.ijid.2019.07.015.
Nigeria Center for Disease control (NCDC) Lassa Fever 2020. Ncdc.gov.ng/diseases/sitreps. (11)
Okogbenin SA, Asogun D, Akpede G, Okokhere P, Gunther S and Happi C. New lessons from a case series review of Lassa fever in pregnancy. IJID; 2010: 14(1): e308.doi: 10.1016/j.ijid.2010.02.466.
Bello OO, Akinajo OR, Odubamowo KH and Oluwashola TAO. Lassa Fever in Pregnancy: Report of 2 cases Seen at the University College Hospital, Ibadan. Case Reports in Obstet Gynaecol; 2016: 1 – 3. http://dx.doi.org/10.1155/2016/9673683.
Asogun D, Okokhere P, Okogbenin S, Akpede G, Gunther S and Happi C. Lassa fever awareness and practices in a Nigerian rural community. IJID; 2010: 14(1): e208.doi: 10.1016/j.ijid.2010.02.1950.
Gomez GB, Foster N, Brals D, Nelissen HE, Bolarinwa OA, Hendriks ME, Boers AC, van Eck D, Rosendaal N, Adenusi P, Agbede K, Akande TM, van
Hensbroek MB, Wit FW, Hankins CA and Schultsz C. Improving maternal care through a state-wide health insurance program: a cost and cost-effectiveness study in rural Nigeria, PLoS One 10 (9) (2015) 1–17 (e0139048), https://doi.org/10.1371/journal.pone.0139048.
Article Metrics
Abstract View
: 671 times
Download : 327 times
Refbacks
- There are currently no refbacks.
