Effect of COVID-19 infection on pregnancy and the possibility of vertical transmission from infected pregnant mothers to fetuses

Mervat Ahmed AbdRabou(1),


(1) Biology Department, College of Science, Jouf University, P.O.Box 2014, Sakaka,
Corresponding Author

Abstract


Coronavirus disease 19 has been predominant in China then transmitted to different countries. The study aimed to evaluate the recent evidences from published papers of potential risks of COVID-19 contagion through gestation and if vertical transmission is possible?. We reviewed several studies on the effect of COVID-19 through pregnancy by using published articles up to June, 2021. Infection with COVID-19 during pregnancy may increase risk of pregnancy problems such as preterm birth and PPROM in few cases, but other researchers establish no COVID-19 contagion was revealed in neonates. Vertical transmission of COVID-19 is feasible, and happens in a small percentage of infected mothers, but other researchers demonstrated no vertical transmission of COVID-19. According to the narrow data, there is no enough evidence for congenital defects to fetuses of infected mother and no sure for vertical transmission. More research must be done to prove the effect of COVID-19 on the fetuses and vertical transmission. (Afr J Reprod Health 2022; 26[1]: 120-124).

References


Lai CC, Shih TP, Ko WC, Tang HJ and Hsueh PR. Severe

acute respiratory syndrome coronavirus 2 (SARSCoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. International journal of antimicrobial agents 2020; 55(3):105924.

WHO. Coronavirus Disease 2019 (COVID-19). Situation

Report—80. Available online: https://www.who.int/docs/default

Centers for Disease Control and Prevention (CDC). Interim

Considerations for Infection Prevention and Control

of Coronavirus Disease 2019 (COVID-19) in Inpatient Obstetric Healthcare Settings. Available from https://www.cdc.gov/coron avirus/2019-nCoV/hcp/infection-control.html.

Perlman S. Another Decade, Another Coronavirus. The New

England journal of medicine 2020; 382(8): 760–762.

Qiao J. What are the risks of COVID-19 infection in

pregnant women?. The Lancet 2020; 395(10226):

-762.

Kontou PI, Braliou GG, Dimou NL, Nikolopoulos G and

Bagos PG. Antibody tests in detecting SARS-CoV-2

infection: a meta-analysis. Diagnostics 2020 ;10(5):

-323.

McIntosh K , Hirsch MS. Bloom, A. Coronavirus disease

(COVID-19). UpToDate Hirsch MS Bloom 2020:5(1)-23-27.

Zhang L, Jiang Y, Wei M, Cheng B H , Zhou X ,Li J and

Hu RH. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua fu chan ke za zhi 2020; 55(3): 166-17.

Yang J, Zheng YA, Gou X, Pu K, Chen Z, Guo Q and

Zhou Y. Prevalence of comorbidities and its effects

in patients infected with SARS-CoV-2: a systematic

review and meta-analysis. International Journal of

Infectious Diseases 2020b; 94: 91-95.

Alfaraj SH., Al-Tawfiq JA and Memish ZA. Middle East

Respiratory Syndrome Coronavirus (MERS-CoV) infection during pregnancy: Report of two cases & review of the literature .J Microbiol Immunol Infect 2019 ; 52(3):501-503..

Yan J, Guo J, Fan C, Juan J, Yu X, Li J, Feng L, Li C, Chen

H, Qiao Y, Lei D, Wang C, Xiong G, Xiao F, He W, Pang Q, Hu X, Wang S, Chen D, Zhang Y, Poon LC and Yang H.. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. American journal of obstetrics and gynecology 2020; 223(1), 111-e1.

Patil UP, Maru S, Krishnan P, Carroll-Bennett R, Sanchez

J, Noble L and Wasserman R. Newborns of COVID19 mothers: short-term outcomes of colocating and

breastfeeding from the pandemic’s epicenter. Journal

of Perinatology 2020; 40(10), 1455-1458.

Kyle MH, Glassman ME, Khan A, Fernández CR, Hanft E,

Emeruwa UN, Scripps T, Walzer L, Liao GV, Saslaw

M, Rubenstein D, Hirsch DS, Keown MK, Stephens A, Mollicone I, Bence ML, Gupta A, Sultan S, Sibblies C, Whittier S, Abreu W, Akita F, Penn A, Orange JS, Saiman L, Welch MG, GyamfiBannerman C, Stockwell MS and Dumitriu D. A

review of newborn outcomes during the COVID-19

pandemic. In Seminars in perinatology 2020; 44(7):

Facchetti F, Bugatti M, Drera E, Tripodo C, Sartori E,

Cancila V, Papaccio M, Castellani R, Casola S, Boniotti MB, Cavadini P and Lavazza A. SARSCoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of Placenta. EBioMedicine 2020;

: 102951.

Fenizia C, Biasin M, Cetin I, Vergani P, Mileto D, Spinillo

A, Gismondo MR, Perotti F, Callegari C, Mancon A, Cammarata S, Beretta I, Nebuloni M, Trabattoni D, Clerici M and Savasi V. Analysis of SARS-CoV-2 vertical transmission during pregnancy. Nature communications 2020; 11(1): 1-10.

Fan C, Lei D, Fang C, Li C, Wang M, Liu Y, Bao Y, Sun

Y, Huang J, Guo Y, Yu Y and Wang S. Perinatal

transmission of 2019 coronavirus disease–associated

severe acute respiratory syndrome coronavirus 2: should we worry?. Clinical Infectious Diseases 2021; 72(5), 862-864.

Della Gatta AN, Rizzo R, Pilu G and Simonazzi G.

COVID-19 during pregnancy: a systematic review of reported cases. American Journal of Obstetrics and Gynecology 2020:27-41.

Yang Z, Wang M, Zhu Z, and Liu Y. Coronavirus disease

(COVID-19) and pregnancy: a systematic review. The Journal of Maternal-Fetal & Neonatal Medicine 2020a: 1-4.

Yang Z and Liu Y.Vertical transmission of severe acute

respiratory syndrome coronavirus 2: a systematic review. American journal of perinatology 2020;37(10): 1055-1059.

Dong L, Tian J, He S, Zhu C, Wang J, Liu C and Yang J.

Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. Jama 2020; 323(18): 1846-1848.

Zeng H , Xu C , Fan J , Tang Y , Deng Q , Zhang W and Long X. Antibodies in infants born to mothers with COVID-19 pneumonia. Jama 2020a; 323(18), 1848-1849

Patanè L, Morotti D, Giunta MR, Sigismondi C, Piccoli

MG, Frigerio L, Mangili G, Arosio M and Cornolti

G. Vertical transmission of COVID-19: SARS-CoV2 RNA on the fetal side of the placenta in pregnancies with COVID-19 positive mothers and neonates at birth. American journal of obstetrics & gynecology 2020: MFM.

Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J and Zhou

W. Neonatal early-onset infection with SARS-CoV2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA pediatrics 2020b; 174(7): 722-725.

Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES and

Goldstein JA. Placental pathology in COVID-19. American journal of clinical pathology, 2020 154(1), 23-32.

Baergen RN and Heller DS. Placental pathology in Covid19 positive mothers: preliminary findings. Pediatric and Developmental Pathology 2020, 23(3): 177-180.

Mulvey JJ, Magro CM, Ma X, Nuovo GJ and Baergen RN.

Analysis of complement deposition and viral RNA in

placentas of COVID-19 patients. Annals of diagnostic pathology 2020;46: 151530.

Lokken EM, Walker CL, Delaney S, Kachikis A, Kretzer

NM, Erickson A, Resnick R, Vanderhoeven J, Hwang JK, Barnhart N, Rah J, McCartney SA, Ma KK, Huebner EM, Thomas C, Sheng JS, Paek BW, Retzlaff K, Kline CR, Munson J, Blain M, LaCourse SM, Deutsch G and Adams Waldorf KM. Clinical characteristics of 46 pregnant women with a severe

acute respiratory syndrome coronavirus 2 infection

in Washington State. American journal of obstetrics

and gynecology 2020; 223(6), 911-e1.

Esin S, Azemi A, Api O, Yayla M and Şen C. COVID-19

during pregnancy and its impacts on perinatal


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