A Shortened versus Standard Matched Postpartum Magnesium Sulphate Regimen in the Treatment of Eclampsia: a Randomised Controlled trial.

Calvin M. Chama, Ado D. Geidam Babagana Bako, Abdulkarim G. Mairiga, Adamu Atterwahmie


Magnesium sulphate is currently the most ideal drug for the treatment of eclampsia but its use in Nigeria is still limited due its cost and clinicians inexperience with the drug. The purpose of this study was to determine whether a shortened postpartum course of magnesium sulphate is as effective as the standard Pritchard regimen in controlling fits in eclampsia. Between January and June 2011, 98 eclamptic mothers presenting at the labour ward of the University of Maiduguri Teaching Hospital were randomised to receive either the standard Pritchard regimen of magnesium sulphate or a shortened postpartum course in which only two doses of intramuscular magnesium sulphate is given four hours apart. The maternal and fetal outcomes were compared. The primary outcome measure was recurrence of fits. The recurrence of fits and other maternal complications were similar in the two groups. The total dosage of magnesium sulphate in the shortened group was reduced by 40% in 66% of patients. The shortened postpartum course of magnesium sulphate is as effective as the standard Pritchard regimen in the management of eclampsia. (Afr J Reprod Health 2013; 17[3]: 131-136).



Le sulfate de magnésium est actuellement le médicament le plus idéal pour le traitement de l'éclampsie, mais son utilisation au Nigeria est encore limitée en raison de son coût et des cliniciens inexpérience avec la drogue. Le but de cette étude était de déterminer si un cours du post-partum raccourcie de sulfate de magnésium est aussi efficace que le traitement standard de Pritchard dans le contrôle unique de l'éclampsie. Entre janvier et juin 2011 98 mères éclampsie qui se présentent à la salle de travail du Centre Hospitalier de l’Université de Maiduguri ont été randomisés pour recevoir soit le traitement de Pritchard  standard de sulfate de magnésium ou d'un cours du post-partum raccourci dans lequel seulement deux doses de sulfate de magnésium par voie intramusculaire sont données quatre heures d'intervalle. Les résultats maternels et fœtaux ont été comparés. Le critère de jugement principal était la récurrence de crises. La récurrence des crises et autres complications maternelles étaient similaires dans les deux groupes. La dose totale de sulfate de magnésium dans le groupe raccourci a été réduite de 40% à 66% des patients. Le cours du post-partum abrégée du sulfate de magnésium est aussi efficace que le traitement standard de Pritchard dans la gestion de l'éclampsie. (Afr J Reprod Health 2013; 17[3]: 131-136).



Keywords: Eclampsia, postpartum magnesium sulphate, shortened regimen

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