Effect of School-based Human Papillomavirus (HPV) Vaccination on Adolescent Girls’ Knowledge and Acceptability of the HPV Vaccine in Ibanda District in Uganda

Andrew Kampikaho Turiho, Elialilia S. Okello, Wilson W. Muhwezi, Steve Harvey, Pauline Byakika-Kibwika, David Meya, Anne R. Katahoire

Abstract

From 2008 to 2011, schoolgirls were vaccinated against HPV in two districts in Uganda following sensitization. This study assessed girls’ knowledge of cervical cancer and HPV vaccine, and their acceptance of future vaccination of friends and hypothetical daughters. The cross-sectional, mixed methods comparative study was conducted in two districts. Univariate, bivariate, logistic regression and thematic analyses were done. HPV vaccination was positively associated with knowledge (Crude OR: 5.31, CI: 3.19-8.86; p = 0.000); but knowledge (Adjusted OR: 1.13, CI: 0.56-2.28; p = 0.73) and HPV vaccination (Adjusted OR: 0.92, CI: 0.16-5.36; p = 0.93) did not predict vaccine acceptability. Seemingly important motivations for vaccine acceptance were: its role in cancer prevention and advancement of reproductive health, minimal side effects, and positive peer role models. Major deterrents to vaccine acceptance were: rumours and misconceptions about possible side effects, perceived inadequate information about vaccine, and fear of side effects. (Afr J Reprod Health 2014; 18[4]: 45-53).

 

Key words: Adolescent girls; knowledge; acceptability; vaccine; Uganda  

  

Résumé

De 2008 à 2011, des écolières ont été vaccinées contre le VPH dans deux districts en Ouganda suite à la sensibilisation. Cette étude a évalué les connaissances  chez les filles à l’égard du cancer du col et le vaccin contre le VPH, et leur acceptation de la vaccination future d'amis et de filles hypothétiques. L’étude transversale  comparative, des méthodes mixtes, a été menée dans deux districts.  La régression logistique uni-variée, bi-variée  et les analyses thématiques ont été réalisées. La vaccination contre le VPH a été positivement associée à la connaissance (OR brut: 5,31, IC: 3,19 à 8,86; p = 0,000); mais la connaissance (OR ajusté: 1,13, IC: 0,56 à 2,28; p = 0,73) et de vaccination contre le VPH (OR ajusté: 0,92, IC: 0,16 à 5,36; p = 0,93) n'ont  pas prédit l'acceptabilité du vaccin.  D’importantes motivations apparentes pour l'acceptation du vaccin étaient: son rôle dans la prévention du cancer et la promotion de santé de la reproduction, des effets secondaires minimes, et les modèles de comportement des pairs positifs. Des obstacles majeurs à l'acceptation du vaccin ont été: les rumeurs et les idées fausses au sujet des effets secondaires possibles, information inadéquate perçue sur le vaccin, et la peur des effets secondaires. (Afr J Reprod Health 2014; 18[4]: 45-53).

 

Mots clés: adolescentes; connaissances; acceptabilité; vaccin; Ouganda

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