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Original
Research Article
The Acute Phase Response
to Parturition: A Cross-Sectional Study in Zimbabwe
Henrik Friis 1, Exnevia Gomo 2, 3,
Wilson Mashange 3, Norman Nyazema 4,
Pernille Kæstel 5, Frank Wieringa 6,
Henrik Krarup 7
1Department
of Human Nutrition, University of Copenhagen, Denmark;
2Research Support Centre,
College of Medicine, University of Malawi, Malawi;
3National Institute of Health
Research (formerly Blair Research Institute), Ministry
of Health and Child Welfare, Zimbabwe;
4Department of Clinical
Pharmacology, University of Zimbabwe, Harare, Zimbabwe;
5Department of Human
Nutrition, Faculty of Life Sciences, University of
Copenhagen, Frederiksberg, Denmark;
6Nutrition, Food and
Societies, Institute of Research for Development,
Montpellier, France;
7Department of Clinical
Biochemistry, Aalborg University Hospital, Aalborg,
Denmark.
*For
correspondence:
Henrik Friis, MD, PhD,
Professor of International Nutrition and Health,
Department of Human Nutrition, Faculty of Life Sciences,
University of Copenhagen,
Rolighedsvej
30, 1958 Frederiksberg, Denmark.
Tel: +45 3533
3860 E-mail:
hfr@life.ku.dk
African Journal of Reproductive Health,
June 2009; 13(2):
61- 68
ABSTRACT
Parturition triggers an
acute phase response, but its magnitude, duration and
predictors are not well described. We determined serum
a1-antichymotrypsin
(ACT) and C-reactive protein (CRP) among 216 women
attending postpartum services in south-eastern Zimbabwe.
Serum CRP peaked during the first week and serum ACT
around 9 days postpartum. Serum ACT, but not serum CRP,
was lower among HIV infected women. Multiparity was a
negative, and preterm delivery and caesarean section
were positive predictors of both serum ACT and CRP.
There is a need for a better understanding of the acute
phase response to parturition
(Afr J Reprod Health 2009;
13[2]:61-68).
RĖSUMĖ
Réponse de la
phase aiguë a la parturition: une étude transversale au
Zimbabwe.
La parturition déclenché une réponse de la phase aiguë,
mais son ampleur, sa durée et ses indices ne Sont pas
bien décrits. Nous avons détermine la sérique
alpha-antichymotrypsin (AAT) et la protéine C-réactive
(PCR) chez 216 femmes qui fréquentaient les services du
post-partum au sud-est du Zimbabwe. La sérique PCR a
atteint le maximum au cours de la première semaine et la
sérique AAT après un post-partum d’à peu près neuf
jours. La sérique AAT (non pas la sérique PCR) était
moins élevée chez les femmes séropositives. La
multiparité était un indice négatif, tandis que
l’accouchement avant terme et l’opération césarienne
étaient des indices positifs de la sérique AAT et PCR.
Il faut une meilleure compréhension de la réponse de la
phase aiguë à la parturition
(Afr J
Reprod Health 2009; 13[2]:61-68).
KEYWORDS:
Acute phase
response, α1-antichymotrypsin, C-reactive
protein, HIV, postpartum, Zimbabwe. |
